This research employs a multi-pronged analysis approach to contribute to the existing knowledge regarding land use and water quality in southern Miami Dade County. Nutrient concentrations for TP, NOx-N, and NH3-N were evaluated for water quality monitoring stations across seven canals for two time periods: 1990-2003 and 2009-2014. Overall, the sites did not surpass the mandated TP threshold but a number of sites exceeded the NOx-N and NH3-N criteria set by multiple government agencies. Statistical tests demonstrated that the sites had differing distributions, not sharing similar median concentrations. Land use classifications were derived for the area interest for the years 1994 and 2013. Regression models relating land use classifications to nutrient concentrations at various spatial scales provided mixed results. Lastly, a trend analysis for nutrient concentrations at the stations for 1990-2003 and 2009-2014 demonstrated that there were either no trends or a decreasing trend at most sites.